Transcriptomic effects of neprilysin inhibition during endothelin-1–induced hypertrophic stress in human iPSC-derived cardiomyocytes

ABSTRACT: Human induced pluripotent stem cell–derived cardiomyocytes were used to investigate the cardiomyocyte-intrinsic effects of neprilysin inhibition during hypertrophic stress. Cardiomyocytes were treated with endothelin-1, the neprilysin inhibitor sacubitrilat, a combination of endothelin-1 and sacubitrilat, or vehicle control. Bulk RNA sequencing was performed to characterize transcriptional remodeling induced by endothelin-1 and to determine whether neprilysin inhibition modifies this response.

ORGANISM(S): Homo sapiens

PROVIDER: GSE335813 | GEO | 2026/06/22

REPOSITORIES: GEO