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Dysregulated thymus-ovary axis promotes virtual memory T cell polarization to aggravate PCOS pathology

ABSTRACT: Polycystic ovary syndrome (PCOS) is characterized by androgen excess, ovarian dysfunction and polycystic ovarian morphology and is classically considered as a disorder of the hypothalamic-pituitary-gonadal (HPG) axis. However, whether organs beyond the reproductive endocrine axis contribute to PCOS pathogenesis remains elusive. Herein, we identified a functional thymus-ovary axis involved in PCOS development.

ORGANISM(S): Mus musculus

PROVIDER: GSE337671 | GEO | 2026/07/11

REPOSITORIES: GEO

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