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Cervical cancer-derived exosomal miR-4508 deficiency promotes tumor progression and M2 macrophage polarization by targeting TRIM59

ABSTRACT: Recurrent cervical cancer (CC) severely threatens women’s health worldwide, and circulating exosomal microRNAs participate in tumor intercellular communication and drive tumor malignant progression. However, the functional mechanism of exosomal miRNAs derived from cervical cancer remains largely unclear. In this study, we performed miRNA-seq on whole blood samples collected from 3 healthy female volunteers and 3 patients pathologically diagnosed with cervical cancer. Raw reads were quality filtered, mapped to GRCh38, and normalized to CPM values to identify differentially expressed miRNAs. miR-4508 was significantly downregulated in patient blood, with the normalized miRNA expression matrix provided as processed data.

ORGANISM(S): Homo sapiens

PROVIDER: GSE338108 | GEO | 2026/09/04

REPOSITORIES: GEO

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