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SRPK2 CLIP-seq reveals direct RNA targets in breast cancer cells

ABSTRACT: SRPK2 (SRSF protein kinase 2) is a serine/arginine-rich protein-specific kinase that phosphorylates splicing factors and regulates alternative splicing. SRPK2 is highly expressed in breast cancer and associated with poor prognosis, and has been implicated in the post-transcriptional regulation of FASN mRNA. To identify the RNAs directly bound by SRPK2 in breast cancer cells, we performed UV-crosslinked iRIP-seq of SRPK2 in MDA-MB-231 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE338304 | GEO | 2026/07/15

REPOSITORIES: GEO

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