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Nanopore and EPIC Array Profiling Unmask an Atypical Non-Midline H3 K27-Altered Glioma: a case report

ABSTRACT: We report a rare adult case of H3K27-altered diffuse glioma arising in an atypical non-midline location, highlighting the diagnostic challenges posed by its radiological and histopathological resemblance to glioblastoma. The study demonstrates the clinical utility of integrated histopathological, methylation-based, and genomic analyses, including rapid Nanopore methylation profiling, for accurate tumor classification and precision neuro-oncology. These findings are of direct relevance to neuropathologists, molecular pathologists, neurooncologists, and translational neuroscience researchers.

ORGANISM(S): Homo sapiens

PROVIDER: GSE338747 | GEO | 2026/09/02

REPOSITORIES: GEO

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