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Targeting epigenetic rheostat Zmynd8 unleashes IL-2 signaling to override T cell exhaustion [bulk ATAC-seq]

ABSTRACT: ATAC analysis of sgNTC and sgZmynd8 Ly108+Tim3- (Texprog) and Ly108-Tim3+ (effector-like) P14 CD8+ T cells at day 14 post LCMV Clone13 chronic infection

ORGANISM(S): Mus musculus

PROVIDER: GSE338943 | GEO | 2026/09/28

REPOSITORIES: GEO

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Targeting epigenetic rheostat Zmynd8 unleashes IL-2 signaling to override T cell exhaustion [scMultiomics]

Project description:Single cell multiomics (10X Genomics) analysis of sgNTC and sgZmynd8 P14 CD8+ T cells at day 21 post LCMV Clone13 chronic infection

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Targeting epigenetic rheostat Zmynd8 unleashes IL-2 signaling to override T cell exhaustion [scRNA-seq]

Project description:Single cell RNA-seq analysis of sgNTC and sgZmynd8 P14 CD8+ T cells at day 21 post LCMV Clone13 chronic infection

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Targeting epigenetic rheostat Zmynd8 unleashes IL-2 signaling to override T cell exhaustion [cutandrun3]

Project description:CUT&RUN analysis of H3K27Ac levels in P14 T cell subpopulations at day 21 post LCMV Clone13 chronic infection.

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Targeting epigenetic rheostat Zmynd8 unleashes IL-2 signaling to override T cell exhaustion [cutandrun2]

Project description:CUT&RUN analysis of histone marks in P14 CD8+ T cells at day 7 post LCMV Clone13 chronic infection.

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Targeting epigenetic rheostat Zmynd8 unleashes IL-2 signaling to override T cell exhaustion [cutandrun1]

Project description:CUT&RUN analysis of IgG, anti–Zmynd8, anti–p300 and anti-H3K27Ac in P14 CD8+ T cells at day 7 post LCMV Clone13 chronic infection

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Targeting epigenetic rheostat Zmynd8 unleashes IL-2 signaling to override T cell exhaustion [scCRISPR]

Project description:The gene regulatory network (GRN) underlying CD8+ T cell differentiation in chronic infection and whether Tex responses can be functionally reinvigorated are incompletely understood. Here, we systematically mapped causal GRNs via single-cell CRISPR (scCRISPR) screens in vivo and discovered regulators for CD8+ T cell differentiation in chronic infection.

2026-09-28 | GSE339143 | GEO

Targeting ZMYND8 unleashes IL-2 signaling to override T cell exhaustion

Project description:This SuperSeries is composed of the SubSeries listed below.

2026-09-23 | GSE342764 | GEO

Targeting ZMYND8 unleashes IL-2 signaling to override T cell exhaustion

Project description:Targeting ZMYND8 unleashes IL-2 signaling to override T cell exhaustion

| PRJNA1508856 | ENA

Gene expression profiling of E1A;HrasG12V mouse embryonic fibroblasts grown under physiological (5%) oxygen conditions, with wild-type p53 or p53 null

Project description:To investigate how pleiotropic the impact of p53 loss is on cellular function, generated isogenic, polyclonal wild-type (sgNTC) and p53-null (sgp53) E1A;HrasG12V mouse embryonic fibroblast cell lines using CRISPR/Cas9. Here we show gene expression analysis on p53 wild-type (sgNTC) and p53null (sgp53) E1A;HrasG12V MEFs grown under physiological oxygen conditions (5% oxygen).

2020-08-07 | GSE136355 | GEO

Viral RNA silencing suppressor and DCL4-associated DRB4 protein interaction is modulated by a viral long non-coding RNA

Project description:The expression of the BNYVV silencing suppressor (VSR) p14 protein, together with the production of a viral non-coding RNA (ncRNA3) affects the long-distance movement on natural host Beta species. Through immunoprecipitation of Flag-p14 and expression of TurboID-p14 coupled to mass spectrometry, we identified several potential p14 cellular partners. These include proteins related to RNA metabolism, proteasome activation, and notably, SGS3 -a key player in the siRNA transitivity pathway- and DRB4, the DCL4 cofactor described in A. thaliana silencing pathways. The interaction between p14 and DRB4 was specifically retrieved with the hypomorphic p14BA2 VSR mutant in nucleoli and was disrupted in the presence of the ncRNA3, a condition that allows the viral mutant to move long distance. Subcellular fractionation of infected tissues revealed that ncRNA3 accumulates in the nucleus thanks to its interaction with p14 while genomic RNA3 remains cytoplasmic. Our results suggest that a specific viral RNA is targeted to nucleus to participate in silencing suppression function through destabilisation of p14-DRB4 complex. Moreover, the putative interaction between p14 and SGS3 provides a mechanistic explanation of the role of this VSR on silencing transitivity.

2026-09-07 | PXD068024 | Pride

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