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Targeting epigenetic rheostat Zmynd8 unleashes IL-2 signaling to override T cell exhaustion [scCRISPR]

ABSTRACT: The gene regulatory network (GRN) underlying CD8+ T cell differentiation in chronic infection and whether Tex responses can be functionally reinvigorated are incompletely understood. Here, we systematically mapped causal GRNs via single-cell CRISPR (scCRISPR) screens in vivo and discovered regulators for CD8+ T cell differentiation in chronic infection.

ORGANISM(S): Mus musculus

PROVIDER: GSE339143 | GEO | 2026/09/28

REPOSITORIES: GEO

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