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Hepatocyte-derived sIL1RAP restrains chronic inflammation under dietary

ABSTRACT: Metabolic dysfunction-associated steatohepatitis (MASH) is characterized by hepatic lipid accumulation, injury, inflammation, and fibrosis, but the endogenous hepatocyte-derived secretory signals that restrain hepatic inflammatory responses under dietary stress remain unclear. In this study, bulk RNA sequencing was performed on liver tissues from control mice fed a chow diet, GAN diet-induced MASH mice treated with a control AAV vector, and GAN diet-induced MASH mice treated with hepatocyte-targeted AAV-sIL1RAP. This dataset was designed to characterize GAN diet-induced hepatic transcriptional alterations and to assess whether restoration of hepatocyte-derived soluble interleukin-1 receptor accessory protein (sIL1RAP) attenuates inflammation-associated transcriptional responses. Comparative transcriptomic analysis showed that the GAN diet enhanced inflammatory transcriptional programs, including NF-κB-related signaling, whereas hepatocyte-specific restoration of sIL1RAP mitigated these changes. These data support a role for hepatocyte-derived sIL1RAP in limiting diet-induced hepatic inflammatory responses.

ORGANISM(S): Mus musculus

PROVIDER: GSE339052 | GEO | 2026/08/13

REPOSITORIES: GEO

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