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Sc-RNAseq of glomerular cells in a mouse model of malignant hypertension

ABSTRACT: Hypertensive emergency (HTEM) is defined by abrupt blood pressure elevation with acute multi‑organ damage, yet the mechanisms predisposing only a subset of hypertensive individuals to HTEM remain unclear. Progress has been limited by the lack of a mouse model that faithfully replicates human disease. We aimed to identify determinants of susceptibility to hypertensive microvascular injury and characterize a murine model of HTEM. Males 129S2/SvPasCrl (129Sv) mice were exposed to severe hypertension via angiotensin II infusion combined with a high‑salt diet wth or withour supplementation with rhPlGF2. We assessed glomerular transcriptional profiles using single‑cell RNA sequencing. Single‑cell transcriptomics revealed profound repression of angiogenic, metabolic, and stress-response pathways in glomerular endothelial cells, a repression partially restored by rhPlGF-2.

ORGANISM(S): Mus musculus

PROVIDER: GSE339100 | GEO | 2026/09/01

REPOSITORIES: GEO

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