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The Histone Demethylase KDM6B Restrains Hypermetabolic LYVE1+ Perivascular Macrophages and Preserves Adipogenic Balance

ABSTRACT: We employed bulk RNA sequencing to study adipose tissue macrophages isolated from epididymal white adipose tissue of wild-type and macrophage-specific KDM6B knockout mice fed a high-fat diet for 5 weeks. This study was designed to identify genotype-dependent transcriptional changes associated with KDM6B deficiency during early diet-induced obesity.

ORGANISM(S): Mus musculus

PROVIDER: GSE339267 | GEO | 2026/09/01

REPOSITORIES: GEO

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The Histone Demethylase KDM6B Restrains Hypermetabolic LYVE1+ Perivascular Macrophages and Preserves Adipogenic Balance [scRNA-Seq]

Project description:We employed single-cell RNA sequencing to study adipose tissue macrophages isolated from epididymal white adipose tissue of wild-type and macrophage-specific KDM6B knockout mice fed a high-fat diet for 5 weeks. This study was designed to identify macrophage subpopulations and genotype-dependent transcriptional changes associated with KDM6B deficiency during early diet-induced obesity. These data provide insights into macrophage heterogeneity, inflammatory activation, lipid-associated macrophage states, and immune remodeling in obese adipose tissue.

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The Histone Demethylase KDM6B Restrains Hypermetabolic LYVE1+ Perivascular Macrophages and Preserves Adipogenic Balance [RNA-seq atm]

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Project description:We employed a bulk RNA sequencing approach to study transcriptional remodeling of white adipose tissue in wild-type and macrophage-specific KDM6B knockout mice fed a high-fat diet for 5 weeks. Subcutaneous white adipose tissue and epididymal white adipose tissue were collected and analyzed, with three biological replicates per group. This study was designed to identify depot-specific and genotype-dependent gene expression changes associated with diet-induced obesity. These data provide insights into macrophage-dependent regulation of adipose tissue inflammation, metabolic dysfunction, extracellular matrix remodeling, and tissue adaptation during chronic high-fat diet feeding.

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The Histone Demethylase KDM6B Restrains Hypermetabolic LYVE1+ Perivascular Macrophages and Preserves Adipogenic

Project description:This SuperSeries is composed of the SubSeries listed below.

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KDM4B- and KDM6B-regulated genes in human mesenchymal stem cell osteogenic differentiation

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