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Intravenous Administration of Stromal Vascular Fraction Attenuates Early Busulfan-Induced Testicular Injury in Rats: An Alternative Cell-Based Approach for Spermatogenic Impairment

ABSTRACT: Chemotherapy can cause lasting damage to the testicles, leading to male infertility. In this study, we tested whether a cell‑based therapy by using a mixture of cells obtained from fat tissue (called stromal vascular fraction, or SVF) could reduce testicular damage in rats treated with busulfan, a chemotherapy drug. We found that giving SVF intravenously immediately after busulfan exposure significantly improved sperm quality and testicular structure within two weeks. Our results suggest that this approach may offer a rapid and practical way to protect against chemotherapy‑induced testicular injury. However, longer‑term studies are needed to confirm whether these early improvements lead to lasting recovery of fertility.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE339598 | GEO | 2026/08/19

REPOSITORIES: GEO

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