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Hidden outcomes of CRISPR/Cas9 genome editing revealed by targeted sequencing in isogenic human iPSC clones [RNA-seq]

ABSTRACT: CRISPR/Cas9 editing can create complex on-target alterations that escape conventional PCR genotyping. We characterized ten edited human induced pluripotent stem cell clones derived from four related parental lines carrying a tandem Xq25 duplication encompassing STAG2. Targeted genomic sequencing revealed inversions, plasmid integration, and complex rearrangements and resolved discrepancies between genotyping and transcriptomic observations. This GEO submission provides quantitative genome-browser coverage tracks supporting the transcriptomic and whole-genome analyses. BioProject: PRJNA1499378.

ORGANISM(S): Homo sapiens

PROVIDER: GSE341489 | GEO | 2026/07/30

REPOSITORIES: GEO

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