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MAOA+ CAFs enforce immune exclusion in pancreatic cancer by restraining serotonin-dependent histone H3Q5 serotonylation

ABSTRACT: Pancreatic ductal adenocarcinoma (PDAC) is characterized by dense desmoplasia and profound T-cell exclusion, yet the stromal metabolic programs that sustain this immune-refractory microenvironment remain poorly understood. Monoamine oxidase A (MAOA) is a mitochondrial enzyme that catalyzes serotonin degradation, but whether this metabolic pathway is co-opted by cancer-associated fibroblasts (CAFs) to regulate antitumor immunity remains unknown.

ORGANISM(S): Mus musculus

PROVIDER: GSE341834 | GEO | 2026/07/29

REPOSITORIES: GEO

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MAOA+ CAFs enforce immune exclusion in pancreatic cancer by restraining serotonin-dependent histone H3Q5 serotonylation

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