The role of Angiopoietin 1 in acute-on-chronic liver failure

ABSTRACT: Acute-on-chronic liver failure (ACLF) is an acute liver and multisystem failure in patients with pre-existing liver disease. A common precipitating factor for ACLF is sepsis. Our recent work shows that sepsis-ACLF is associated with loss of Angiopoietin 1 (ANG-1) and endothelial dysfunction that in turn promotes loss of hepatocyte differentiation and liver failure. However, the mechanism of angiopoietin-mediated endothelial to hepatocyte crosstalk in ACLF is not fully understood. We aimed to study Angiopoietin 1-induced changes in liver cells using spatial transcritomics.

ORGANISM(S): Mus musculus

PROVIDER: GSE342343 | GEO | 2026/09/01

REPOSITORIES: GEO