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TLR7 Agonist Nanomedicine Suppresses Lung Metastasis of Osteosarcoma by Remodeling the Immune Microenvironment

ABSTRACT: This study aimed to evaluate a TLR7 agonist liposome (1V209-Cho-Lip) for its anti-metastatic effects and mechanisms in osteosarcoma. Single-cell transcriptomics analysis demonstrated that treatment with 1V209-Cho-Lip alleviates myeloid-mediated immunosuppression, promotes CD8+ T cell activation and clonal expansion, and improves intercellular communication between tumor cells and immune cells.

ORGANISM(S): Mus musculus

PROVIDER: GSE342815 | GEO | 2026/08/12

REPOSITORIES: GEO

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TLR7 Agonist Nanomedicine Suppresses Lung Metastasis of Osteosarcoma by Remodeling the Immune Microenvironment

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