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Transcriptomic profiling of CCL2-high and CCL2-low glioma cell states

ABSTRACT: Glioma cells can reversibly occupy cellular states with distinct contributions to tumor growth and microenvironmental remodelling. To define transcriptional programmes associated with endogenous Ccl2 activity, CCL2-high and CCL2-low cells were isolated from endogenous Ccl2 reporter cells by fluorescence-activated cell sorting and analysed using one-colour gene-expression microarrays. The resulting profiles were used to identify genes and pathways preferentially represented in the CCL2-high niche-remodelling state or the CCL2-low proliferative state.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE345749 | GEO | 2026/09/06

REPOSITORIES: GEO

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