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Spatial compartmentalization shapes distinct germinal center states during respiratory viral infection

ABSTRACT: Germinal centers (GCs) typically form within the lymph node cortex, but whether proliferating B-cell aggregates in the medulla engage GC-associated programs remains unclear. In this study, mediastinal lymph nodes from SARS-CoV-2-infected cynomolgus macaques were analyzed using Xenium spatial transcriptomics to characterize conventional cortical GCs (cGCs) and LYVE1-associated medullary GC structures (mGCs). A 377-target Xenium Human Multi-Cancer Panel was used to profile their transcriptional, cellular, and spatial features. The dataset enables comparison of GC organization across distinct anatomical compartments within lung-draining lymph nodes.

ORGANISM(S): Macaca fascicularis

PROVIDER: GSE346722 | GEO | 2026/09/13

REPOSITORIES: GEO

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