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Differentially expressed genes in recurrence of squamous cell carcinoma tumors of the oral cavity in a mouse model

ABSTRACT: We applied global gene expression with samples derived from a recently established mouse model for oral cancer recurrences and identified a list of genes with differential expression between primary and recurrent tumors.

ORGANISM(S): Mus musculus

PROVIDER: GSE35377 | GEO | 2012/01/28

SECONDARY ACCESSION(S): PRJNA152613

REPOSITORIES: GEO

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Differentially expressed genes in recurrence of squamous cell carcinoma tumors of the oral cavity in a mouse model

Project description:We applied global gene expression with samples derived from a recently established mouse model for oral cancer recurrences and identified a list of genes with differential expression between primary and recurrent tumors. 5 independent primary tumors and respectivce recurrences were analyzed. Two replicates of the original cell line used for the generation of all tumors was also added to the study.

2012-01-28 | E-GEOD-35377 | biostudies-arrayexpress

Genetic expression of stage IV oral squamous cell carcinoma according to the recurrence

Project description:To characterize differential gene expression patterns and their actual expression in tissues for recurrent and non-recurrent tumors to identify independent prognostic markers for oral squamous cell carcinoma (OSCC).

2019-09-30 | GSE87593 | GEO

Response and recurrence correlates in patients treated with neoadjuvant anti-PD-1 therapy for resectable oral-cavity squamous cell carcinoma

Project description:Neoadjuvant PD-1 blockade may be efficacious in patients with high-risk, resectable oral-cavity, head-and-neck cancer. To explore correlates of response patterns to neoadjuvant nivolumab treatment and post-surgical recurrences, we analyzed longitudinal tumor and blood samples in a cohort of 12 patients displaying 33% responsiveness. Pretreatment tumor-based detection of FLT4 mutations and PTEN signature enrichment favors response, and high tumor mutational burden improves recurrence-free survival. In contrast, preexisting and/or acquired mutations (in CDKN2A, YAP1, JAK2) correlate with innate resistance and/or tumor recurrence. Immunologically, tumor response after therapy entails T-cell receptor repertoire diversification in peripheral blood and intratumoral expansion of preexisting T-cell clones. A high ratio of regulatory to Th17 T cells in pretreatment blood predicts innate resistance, low cytolytic T-cell signature in pretreatment tumor, and low T-cell receptor repertoire diversity in pretreatment blood. Our study provides a molecular framework to advance neoadjuvant anti-PD-1 therapy for patients with resectable head-and-neck cancer.

2021-09-30 | GSE179730 | GEO

Oral cavity

Project description:Oral cavity Targeted loci

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Array comparative genomic hybridization in oral cavity (head and neck) squamous cell carcinoma

Project description:Genome wide high resolution assay of copy number in a series of frozen, microdissected head and neck cancers originating from the oral cavity. The objective was to characterize areas of amplification and deletion in head and neck cancers arising from the oral cavity subsite.

2012-04-01 | GSE33983 | GEO

Array comparative genomic hybridization in oral cavity (head and neck) squamous cell carcinoma

2012-03-31 | E-GEOD-33983 | biostudies-arrayexpress

Human oral cavity

Project description:Human oral cavity metagenome and metatranscriptome

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Transcription profiling of oral cavity samples from human squamous cell carcinoma patients

Project description:Metastasis via the lymphatics is a major risk factor in squamous cell carcinoma of the oral cavity (OSCC). We sought to determine whether the presence of metastasis in the regional lymph node could be predicted by a gene expression signature of the primary tumor. A total of 18 OSCCs were characterized for gene expression by hybridizing RNA to Affymetrix U133A gene chips. Genes with differential expression were identified using a permutation technique and verified by quantitative RT-PCR and immunohistochemistry. A predictive rule was built using a support vector machine, and the accuracy of the rule was evaluated using crossvalidation on the original data set and prediction of an independent set of four patients. Metastatic primary tumors could be differentiated from nonmetastatic primary tumors by a signature gene set of 116 genes. This signature gene set correctly predicted the four independent patients as well as associating five lymph node metastases from the original patient set with the metastatic primary tumor group. We concluded that lymph node metastasis could be predicted by gene expression profiles of primary oral cavity squamous cell carcinomas. The presence of a gene expression signature for lymph node metastasis indicates that clinical testing to assess risk for lymph node metastasis should be possible.

2007-08-25 | E-GEOD-2280 | biostudies-arrayexpress

Prediction of lymphatic metastasis from primary squamous cell carcinoma of the oral cavity

2005-02-19 | GSE2280 | GEO

New prognostic factor identification by screening changes in differentially expressed genes during oral squamous cell carcinoma progression

Project description:Identification of differentially expressed genes in human oral squamous cell carcinoma cell line UPCI-SCC-040 after TGF-ß1 treatment compared to untreated controls

2021-05-18 | GSE163241 | GEO

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