Transcriptomics,Genomics

Dataset Information

54

Expression profiling of purified hematopoietic stem cells from patients with MDS and healthy controls


ABSTRACT: Gene expression analysis on purified human long-term hematopoietic stem cells (LT-HSC; CD34+CD38-CD90+) and short-term HSC (ST-HSC; CD34+CD38-CD90-) derived from healthy control patients and patients with myelodysplastic syndrome (MDS) Overall design: Analysis of gene experssion of ST-HSCs and LT-HSCs derived from two patients with MDS and three healthy controls

INSTRUMENT(S): [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]

SUBMITTER: Britta Will  

PROVIDER: GSE38955 | GEO | 2012-08-01

SECONDARY ACCESSION(S): PRJNA169412

REPOSITORIES: GEO

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Publications


Even though hematopoietic stem cell (HSC) dysfunction is presumed in myelodysplastic syndrome (MDS), the exact nature of quantitative and qualitative alterations is unknown. We conducted a study of phenotypic and molecular alterations in highly fractionated stem and progenitor populations in a variety of MDS subtypes. We observed an expansion of the phenotypically primitive long-term HSCs (lineage(-)/CD34(+)/CD38(-)/CD90(+)) in MDS, which was most pronounced in higher-risk cases. These MDS HSCs  ...[more]

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