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ChIP-chip to determine the regulation of the binding targets of a2 and alpha2 in Lachancea kluyveri

ABSTRACT: We examine how different transcriptional network structures can evolve from a common, ancestral network. We show that regulatory protein modularity, conversion of one cis-regulatory sequence to another, distribution of binding energy among protein-protein and protein-DNA interactions, and exploitation of ancestral network features all contribute to the evolution of a novel mode of regulation at a conserved gene set. The formation of this derived mode of regulation did not disrupt the ancestral mode and thereby created a hybrid regulatory state where both means of transcription regulation (ancestral and derived) contribute to the conserved expression pattern of the network. Finally, we show how this hybrid regulatory state has resolved in different ways in different lineages to generate the diversity of regulatory network structures observed in modern species.

ORGANISM(S): Lachancea kluyveri

PROVIDER: GSE39007 | GEO | 2012/06/29

SECONDARY ACCESSION(S): PRJNA169571

REPOSITORIES: GEO

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