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Changes in histone modifications H3K4me2, H3k27me3 and H3K36me3 due to phenobarbital in mice

ABSTRACT: 29-32 days old male mice where either treated with Phenobarbital or untreated

ORGANISM(S): Mus musculus

PROVIDER: GSE41399 | GEO | 2012/11/10

SECONDARY ACCESSION(S): PRJNA179303

REPOSITORIES: GEO

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Changes in histone modifications H3K4me2, H3k27me3 and H3K36me3 due to phenobarbital in mice

Project description:29-32 days old male mice where either treated with Phenobarbital or untreated Replicated control/treated study with IP and Input per group and antibody

2012-11-10 | E-GEOD-41399 | biostudies-arrayexpress

Dynamic changes in liver 5-hydroxymethylcytosine profiles upon non-genotoxic carcinogen exposure

Project description:29-32 days old male mice where either treated with Phenobarbital or untreated

2012-09-12 | GSE40773 | GEO

Dynamic changes in liver 5-hydroxymethylcytosine profiles upon non-genotoxic carcinogen exposure

Project description:29-32 days old male mice where either treated with Phenobarbital or untreated Replicated control vs. pb treated study

2012-09-12 | E-GEOD-40773 | biostudies-arrayexpress

Sf9 induction with phenobarbital

Project description:Effect of phenobarbital on Sf9 cell cultures genes expression. RNA from phenobarbital treated Sf9 cell cultures were compared to control treated (DMSO) Sf9 cell

2018-09-22 | GSE32337 | GEO

Diet and phenobarbital affect cholesterol homeostasis and drug metabolism

Project description:High cholesterol diet and xenobiotic treatment induce changes in cholesterol homeostasis and drug metabolism. Mice were either 7 days on high cholesterol diet or were treated with phenobarbital. Liver samples were analyzed using Sterolgene v0 cDNA microarrays. Sterolgene microarray is a tool designed to enable focused studies of cholesterol homeostasis and drug metabolism. We show that one week of cholesterol diet down-regulates cholesterol biosynthesis and up-regulates xenobiotic metabolism (Cyp3 family). Phenobarbital treatment also up-regulates xenobiotic metabolism (Cyp2b and Cyp3a families). We can conclude that the Sterolgene series of cDNA microarrays represent novel original tool, enabling focused and cost-wise studies of cholesterol homeostasis and drug metabolism. Keywords: Treatment and diet effects One group of mice was treated i.p. with 50 mg/kg of phenobarbital in vehicle (5% DMSO in corn oil). Untreated group was injected vehicle. Third group was 7 days on 1 % (w/w) cholesterol diet prior vehicle treatment. After 10 h animals were sacrificed and livers were stored. Pools of total RNA from two animals were mixed. Three pools of untreated and phenobarbital treated groups, and two pools of cholesterol diet group were co-hybridized with liver reference on Sterolgene v0 cDNA microarray. No dye-swaps were performed.

2010-05-25 | E-GEOD-6447 | biostudies-arrayexpress

The alterations of proteins expression related to insulin signaling pathway in the brain of phenobarbital addictive rats by TMT

Project description:Drug addiction is a chronic relapsing brain disease. The alterations of glucose uptake and metabolism were found in the brain of drug addicts. Insulin mediates brain glucose metabolism and its abnormality could induce brain injury and cognitive impairment. Here, we established a rat model of phenobarbital addiction by 90 days dosed escalation and evaluated addiction-related symptoms. We also performed proteomic analysis of the function of the differentially expressed (DE) proteins via bioinformatics in brain tissues by LC-MS/MS on day 60 and 90 of phenobarbital or 0,5% CMC-Na (vehicle) administration. The results showed that phenobarbital addictive rats developed severe withdrawal symptoms after abstinence. Proteomics analysis showed that numerous DE proteins were enriched after phenobarbital administration; which CALM1, ARAF and Cbl proteins (related to insulin signaling pathway) were significantly downregulated on day 60 but no day 90; however, SLC27A3 and NF-kB1 proteins (related to insulin resistance) were significantly upregulated on day 90. Our data indicate that insulin signaling pathway and insulin resistance may play a role in the development of phenobarbital addiction and brain injury and the findings may have important clinical implication.

2020-10-29 | PXD021101 | Pride

Effect of Phenobarbital on Rat Primary Hepatocytes.

Project description:This study provides an evaluation of changes in gene expression associated with phenobarbital treatment of rat hepatocytes in vitro. Primary rat hepatocytes were treated for 24 and 48 hours with two doses (300 uM and 3 mM) of phenobarbital and water vehicle control. Five replicates of each treatment were performed. Cells were then extracted and RNA processed for microarray analysis.

2012-08-28 | GSE40339 | GEO

Irinotecan Plus Cyclosporine and Phenobarbital in Treating Patients With Solid Tumors or Lymphoma

Project description:Phase I trial to study the effectiveness of irinotecan plus cyclosporine and phenobarbital in treating patients who have solid tumors or lymphoma that is refractory to standard therapy. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Cyclosporine and phenobarbital may enhance the effectiveness of irinotecan.

| 2002394 | ecrin-mdr-crc

Expression differences related to phenobarbital feeding in worker honey bees

Project description:The drug phenobarbital induces cytochrome P450 monooxygenase (P450) gene expression in many animals, but no changes in P450 expression, or expression of any detoxification genes, were observed in worker honey bees fed on phenobarbital-candy relative to bees fed plain candy. Keywords: Expression profiling by array

2012-05-12 | GSE34029 | GEO

Transcription profiling of mouse liver treated with phenobarbital and fed a high cholesterol diet an

2008-06-15 | E-GEOD-6721 | biostudies-arrayexpress

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