Transcriptomics

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Global gene expression analysis of peripheral blood cells, pluripotent cell lines, and iPS-derived T cells


ABSTRACT: Exhaustion of antigen-specific T cells represents a major challenge to adoptive immunotherapy against many types of cancer and viral infection. In an effort to overcome this problem, we reprogrammed clonally expanded antigen-specific CD8+ T cells from an HIV-1-infected patient to pluripotency. The T cell-derived induced pluripotent stem cells (T-iPSCs) were then redifferentiated into CD8+ T cells that had high proliferative capacity and elongated telomeres. To confirm that T-iPSCs were compatible to other embryonic stem cells (ESCs) but different from T cells, and that redifferentiated T cells were compatible to T cells but different from natural killer (NK) cells, we analyzed and compared the gene expression profiles of the samples by cDNA microarray. These analyses revealed that our T-iPSCs and redifferentiated T cells were essentially the same as their counterpart pluripotent stem cells and T cells, respectively.

ORGANISM(S): Homo sapiens

PROVIDER: GSE43136 | GEO | 2012/12/25

SECONDARY ACCESSION(S): PRJNA184700

REPOSITORIES: GEO

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