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Cold-induced changes in gene expression in brown adipose tissue, white adipose tissue and liver

ABSTRACT: Cold exposure imposes a metabolic challenge to mammals that must be met by a coordinated repsonse in different tissues to prevent hypothermia. This study reports analysis of transcriptome profiles in brown adipose tissue, liver, white adipose of mice in repsonse to 24 hour cold exposure

ORGANISM(S): Mus musculus

PROVIDER: GSE44138 | GEO | 2013/07/08

SECONDARY ACCESSION(S): PRJNA188763

REPOSITORIES: GEO

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Cold-induced changes in gene expression in brown adipose tissue, white adipose tissue and liver

Project description:Cold exposure imposes a metabolic challenge to mammals that must be met by a coordinated repsonse in different tissues to prevent hypothermia. This study reports analysis of transcriptome profiles in brown adipose tissue, liver, white adipose of mice in repsonse to 24 hour cold exposure Total RNA was extracted from brown adipose, whie adipose and liver from cold treated and control plants. 3 replicates of brown adipose and white adipose and 2 replicates of liver samples.

2013-07-08 | E-GEOD-44138 | biostudies-arrayexpress

Paternal cold exposure enhances brown adipose tissue sensitivity in offspring and ameliorates diet induced obesity

Project description:Research in recent years has focused on environmental effects that control tissue functionality and systemic metabolism. We show here in a retrospective analysis that presence of brown adipocytes and date of birth are correlated and linked to BMI. In a mouse model system, we demonstrate that pre-conception cold exposure leads to improved systemic metabolism and protects from diet induced obesity, through the sperm via the paternal lineage. Using a brown fat ablation model, we show that this effect is mediated by brown adipose tissue. Furthermore, through RNAseq and DNA methylation analysis we identify Adrb3 as a putative signaling mechanism which could mediate the effects of pre-conception cold exposure and could account for the heterogeneity of brown adipose tissue responsiveness. Taken together, our results identify paternal cold exposure as a stimulus which induces a hyper-active state in brown adipose tissue leading to improved adaptation to overnutrition and hypothermia in the offspring.

2018-06-30 | GSE100231 | GEO

Transcriptome profiling of brown adipose tissue during cold exposure

Project description:We applied a deep-sequencing based method – digital gene expression profiling (DGEP), to investigate gene expression in interscapular brown adipose tissue (iBAT), inguinal white adipose tissue (iWAT) and epididymal white adipose tissue (eWAT) in acute cold exposure Examination of gene expression level in 3 different adipose tissues in 3 time points, day0, day2 and day4 in cold exposure.

2014-12-19 | E-GEOD-63031 | biostudies-arrayexpress

Transcriptome profiling of brown adipose tissue during cold exposure

2014-12-19 | GSE63031 | GEO

TMT-based quantitative proteomic analysis of extracellular vesicles (EVs) released from brown/white adipose tissue following cold exposureTMT-based quantitative proteomic analysis of extracellular vesicles (EVs) released from brown/white adipose tissue following cold exposure

Project description:The proteome cargo of extracellular vesicles released from brown adipose tissue (BAT) and from white adipose tissue (WAT) of mice subjected to cold exposure (4°C) was analysed by a TMT-based quantitative proteomic procedure in order to obtain new information on the processes of thermogenesis.

2022-05-20 | PXD026080 | Pride

The acute cold response of brown adipose tissue analyzed by RNA-seq

Project description:We applied RNA sequencing (RNA-seq) to map the global changes in gene expression of interscapular brown adipose tissue (iBAT) of mice subjected to acute cold exposure for 3 days. Here we find extensive changes in the iBAT transcriptome in response to cold with a prominent induction of genes associated to lipid-related metabolic processes. RNA-seq of poly-A enriched RNA isolated from brown adipose tissue of 5 mice housed at room temperature (22Â°C) and 5 mice exposed to cold (4Â°C) for 3 days.

2015-11-25 | E-GEOD-70437 | biostudies-arrayexpress

The acute cold response of brown adipose tissue analyzed by RNA-seq

2015-11-25 | GSE70437 | GEO

Maternal Cold Exposure Enhances Fetal Brown Adipose Tissue Development

Project description:Maternal Cold Exposure Enhances Fetal Brown Adipose Tissue Development

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Macrophage specific Mafb deficiency effects brown adipose tissue's cold adaptability

Project description:To investigate the Cold exposure adaptation under macrophage-specific Mafb deficiency, we put the Mafbf/f (Control) mice and Mafbf/f::LysM-cre (Macrophage specific Mafb deficient) under cold exposure for 10 days and collected the interscapular brown adipose tissue (iBAT) of these mice to compare the changes using RNA sequencing.

2024-02-29 | GSE225421 | GEO

Adipose tissue exposed to cold

Project description:Cold triggers VEGF dependent but hypoxia independent angiogenesis in adipose tissues and anti-VEGF agents modulate adipose metabolism The molecular mechanisms of angiogenesis in relation to adipose tissue metabolism remain poorly understood. Here we show that exposure of mice to cold led to conversion of white adipose tissue (WAT) to brown-like adipose tissue, accompanying the switch of an active angiogenic phenotype. Gene expression profile analysis showed VEGF was upregulated via most likely hypoxia-independent PGC-1 transcriptional activation. Intriguingly, VEGFR2 blockage abolished the cold-induced angiogenesis, significantly impaired nonshivering thermogenesis capacity, and markedly reduced adipose metabolism. Unexpectedly, VEGFR1 blockage resulted in opposite effects by increasing adipose vascularity and metabolism. These findings demonstrate that VEGFR2 and VEGFR1 mediate polarized activities in modulating adipose angiogenesis and metabolism. Taken together, our findings have conceptual implications in applying angiogenesis modulators for the treatment of obesity and metabolic disorders. Keywords: Time course

2009-02-01 | GSE13432 | GEO

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