Genomics

Dataset Information

0

Molecular Signatures of Muscle Rehabilitation After Limb Disuse


ABSTRACT: We have identified the molecular (transcriptional) signatures associated with muscle remodeling in response to rehabilitation in a patient cohort. Subjects with a closed malleolus fracture treated conservatively with 6 weeks of cast immobilization are recruited. Then subjects are enrolled in a 6 weeks structured rehabilitation program focusing on progressive resistance training of the ankle plantar flexor muscles. Phenotypic measurements are performed before (pre-rehab), during (mid-rehab, 3 weeks) and immediately after (post-rehab, 6 weeks) the rehabilitation intervention. The maximal cross-sectional area (muscle size) and peak torque (muscle strength) are quantified using isometric and isokinetic tests in combination with 3D-magnetic resonance imaging. Ankle plantar flexor muscle size and strength measurements are also performed on the uninvolved limb (serves as a control) at 4 months post-immobilization. Measurements are also acquired from the contralateral leg, which serves as an internal control.

ORGANISM(S): Homo sapiens

PROVIDER: GSE45462 | GEO | 2017/08/31

SECONDARY ACCESSION(S): PRJNA194086

REPOSITORIES: GEO

Similar Datasets

2009-02-21 | GSE14901 | GEO
| E-GEOD-14901 | biostudies-arrayexpress
2022-08-25 | PXD034908 | Pride
2020-11-30 | GSE160827 | GEO
2019-04-01 | GSE97312 | GEO
2022-09-28 | GSE185560 | GEO
2023-11-06 | PXD045483 | Pride
| E-GEOD-62897 | biostudies-arrayexpress
2022-12-16 | GSE213148 | GEO
2019-04-01 | GSE97313 | GEO