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Genome-wide DNA methylation aberrations in human atherosclerosis (450K)

ABSTRACT: Epigenetics may help understanding the molecular mechanisms of atherosclerosis as genetic predisposition explains only part of cardiovascular disease risk. In particular, DNA methylation, a reversible and highly regulative DNA modification could contribute to disease onset and progression as it functions as effector for environmental impacts, including dietary and life-style, similarly to risk factors for cardiovascular diseases. We addressed this issue by performing whole-genome shotgun bisulfite sequencing and high-resolution DNAmethylation array analysis of healthy and diseased donor-matched atherosclerotic DNA methylomes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE46394 | GEO | 2014/08/12

SECONDARY ACCESSION(S): PRJNA200087

REPOSITORIES: GEO

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Genome-wide DNA methylation aberrations in human atherosclerosis (450K)

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