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Temporal profiling in muscle regeneration.

ABSTRACT: Temporal expression profiling was utilized to define transcriptional regulatory pathways in vivo in a mouse muscle regeneration model. Potential downstream targets of MyoD were identified by temporal expression, promoter data base mining, and gel shift assays; Slug and calpain 6 were identified as novel MyoD targets. Slug, a member of the snail/slug family of zinc finger transcriptional repressors critical for mesoderm/ectoderm development, was further shown to be a downstream target by using promoter/reporter constructs and demonstration of defective muscle regeneration in Slug null mice. Keywords: other

ORGANISM(S): Mus musculus

PROVIDER: GSE469 | GEO | 2003/07/16

SECONDARY ACCESSION(S): PRJNA85083

REPOSITORIES: GEO

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