Transcriptomics,Genomics

Dataset Information

38

TNF dependent induction of inhibitory pathways in CD4+ T cells in HIV and LCMV [TNF stimulation]


ABSTRACT: Chronic viral infections caused by HIV in humans or LCMV in mice are characterized by immunodeficiency and chronic inflammation. During chronification, T cells progressively lose effector functions, a process associated with immunoregulatory pathways and known as T-cell exhaustion. A link between ‘exhaustive’ T-cell reprogramming and chronic inflammation has not been established. Using a systems biology approach we demonstrate in HIV and LCMV infection that TNF, a prototypical mediator of chronic inflammation, functions upstream of major immunoregulatory pathways in T cells during chronic viral infection. In vivo blockade of TNFR-signaling interferes with the exhaustive T-cell program during chronic infection and reduces viral loads by several log. Continuous TNFR-signaling during disease progression towards chronic infection seems to be causative for T-cell exhaustion and an important link between immunodeficiency and chronic inflammation. TNF blockade might represent a novel therapeutic option during late stage infections caused by HIV and other virus causing chronic infections. TNF stimulation of CD4+ T cells to generate a CD4+ T-cell specific RNA-fingerprint Overall design: 4 experimental conditions with 3 biological replicates for each condition

INSTRUMENT(S): Illumina HumanHT-12 V3.0 expression beadchip

SUBMITTER: Joachim Schultze  

PROVIDER: GSE52182 | GEO | 2016-03-07

SECONDARY ACCESSION(S): PRJNA227133

REPOSITORIES: GEO

Similar Datasets

| GSE17606 | GEO
| GSE52184 | GEO
| GSE17946 | GEO
| GSE52183 | GEO
2015-01-01 | S-EPMC4349940 | BioStudies
1000-01-01 | S-EPMC2493338 | BioStudies
1000-01-01 | S-EPMC5512335 | BioStudies
2016-01-01 | S-EPMC4886784 | BioStudies
1000-01-01 | S-EPMC3204218 | BioStudies
2013-01-01 | S-EPMC3694087 | BioStudies