Transcriptomics,Genomics

Dataset Information

20

Global transcriptome profile of S aureus treated with celecoxib and ampicillin in combination


ABSTRACT: We have previously shown that celecoxib, a selective COX-2 inhibitor, in combination with antibiotic sensitizes S aureus to antibiotic thereby decreasing the MIC of antibiotic. The present study is aimed at understanding the molecular mechanism of action of celecoxib on S aureus growth by microarray analysis. The results were analysed and the data clearly shows global change in the expression levels of S aureus genes in presence of celecoxib. Many virulence genes, essential genes and nonessential genes are down-regulated in presence of celecoxib in combination with ampicillin when compared to drug treatment alone. Overall design: Agilent one-color experiment, Organism: Staphylococcus aureus , Agilent Custom Staphylococcus aureus 8x15k designed by Genotypic Technology Private Limited (AMADID: 27491)

INSTRUMENT(S): Custom Staphylococcus aureus 8x15k Gene Expression Microarray (AMADID:27491)

SUBMITTER: Arunasree M. Kalle  

PROVIDER: GSE56100 | GEO | 2015-06-02

SECONDARY ACCESSION(S): PRJNA242412

REPOSITORIES: GEO

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