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Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes

ABSTRACT: We report the profiling of induced mRNA transcripts in two C. elegan replicate populations -- WT (N2) and mutant strain with deficient HLH30. Both strains were fed either OP50 strain of e-coli (normal feed) or S. aureus

ORGANISM(S): Caenorhabditis elegans

PROVIDER: GSE57739 | GEO | 2015/06/04

SECONDARY ACCESSION(S): PRJNA247976

REPOSITORIES: GEO

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Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes

Project description:We report the profiling of induced mRNA transcripts in two C. elegan replicate populations -- WT (N2) and mutant strain with deficient HLH30. Both strains were fed either OP50 strain of e-coli (normal feed) or S. aureus Examination of infected versus uninfected wildtype and mutant lawns of animals

2015-06-04 | E-GEOD-57739 | biostudies-arrayexpress

Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes.

Project description: Not available

| S-EPMC4104614 | biostudies-literature

Gene expression profiling to study the influence of OP50 diet on lifespan of C. elegans.

Project description:Transcriptome profiling of C. elegans wildtype strain (N2) fed heat-inactivated OP50 diet for 5 days after L4 larvae stage. Jena Centre for Systems Biology of Ageing - JenAge (www.jenage.de)

2021-10-19 | GSE110844 | GEO

Protein EV contents from C. elegans

Project description:The hermaphrodite strain N2 (Bristol), fed with Escherichia coli OP50, was maintained and synchronized. Young adults were thoroughly washed before incubations for 5 h or 24 h in M9 buffer. Between 35,500 and 158,000 worms were used for each experiment. After incuabtion, supernatants were processed by differential centrigugation/ultracentrifugation to pellet extracellular vesicles and characterization of the protein contents by mass spectrometry.

2020-05-04 | PXD017352 | Pride

Response of C. elegans immune pathway mutants to P. aeruginosa infection

Project description:Synchronized C. elegans cultures of three geontypes -- wildype N2, daf-2(e1370) and sma-6(wk7) -- were prepared using standard techniques (http://cmgm.stanford.edu/~kimlab/index_methods.html). Live young adult worms were split between NG plates pre-seeded with the non-pathogenic E. coli strain OP50 or the Pseudomonas aeruginosa clinical isolate PA14 and incubated at 25C for 4 or 24 hours before harvesting. This experiment was repeated at least three times on independent occasions. cDNA probes were prepared from experimental samples and from reference mRNA extracted from mixed stage wild type worms grown at 25C, and were labeled with Cy3 or Cy5, as indicated. A reference experiement design type is where all samples are compared to a common reference. Elapsed Time: Time Infection: Exposure to the non-pathogenic E. coli strain OP50 or to the pathogenic Pseudomonas aeruginosa strain PA14 Strain Name: C. elegans wildtype strain N2 or the immune pathway mutants daf-2(e1370) or sma-6(wk7) Keywords: reference_design

2008-11-06 | GSE13473 | GEO

Caenorhabditis elegans infected with Staphylococcus aureus

Project description:Young adult fer-15;fem-1 Caenorhabditis elegans were infected with Staphylococcus aureus for 8 h to determine the transcriptional host response to Staphylococcus aureus. Analysis of differential gene expression in C. elegans young adults exposed to two different bacteria: E. coli strain OP50 (control), wild-type Staphylococcus aureus RN6390. Samples were analyzed at 8 hours after exposure to the different bacteria. These studies identified C. elegans genes induced by pathogen infection. Keywords: response to pathogen infection, innate immunity, host-pathogen interactions

2010-06-12 | GSE21819 | GEO

C. elegans embryonic timecourse in wt and mutant embryos

Project description:This series of samples comprises multiple early embryonic time courses for C. elegans. Time courses consisting of 10 time points each for 4 different genotypes are included: wild-type (strain N2 grown on E. coli strain OP50), pie-1(zu154) (progeny of homozygous mutant mothers [Unc] of strain JJ532 grown on E. coli strain OP50), pie-1(zu154);pal-1(RNAi) (progeny of homozygous mutant mothers [Unc] of strain JJ532 grown on E. coli strain HT115 expressing pal-1 hairpin RNA), and mex-3(zu155);skn-1(RNAi) (progeny of homozygous mutant mothers [Dpy] of strain JJ518 grown on E. coli strain HT115 expressing skn-1 hairpin RNA). Embryos were manually staged by morphology at the 4-cell stage and allowed to develop in water for defined amounts of time at 22 degrees C. RNA was amplified as described (Baugh et al. Development, 2003; Baugh et al. Nucleic Acids Research, 2001). This series of samples comprises all replicate data reported by Baugh et al. (Development, 2005). Keywords: time-course

2005-04-01 | GSE2180 | GEO

Transcriptional profiling of C. elegans on pathogenic Pseudomonas aeruginosa

Project description:RNA-seq of Wild Type (N2), pmk-1 or atf-7 mutant animals exposed to either non-pathogenic E. coli OP50 or pathogenic P. aeruginosa PA14

2019-02-01 | GSE119292 | GEO

Transcriptomic analysis of stress response to novel antimicrobial coatings in a clinical MRSA strain

Project description:Effect of two different antimicrobial materials, functionalized graphene oxide (GOX), and AGXX® coated on cellulose fibers, on the growth and transcriptome of the clinical MRSA strain S. aureus 04-02981. In addition, we investigated the effect of a third material as a combination of GOX and AGXX® fibers on S. aureus 04-02981

2020-04-22 | GSE149013 | GEO

P. pacificus and C. elegans exposed to various pathogens

Project description:This SuperSeries is composed of the following subset Series: GSE36413 : C. elegans young adults : Exposed to Bacillus thuringiensis DB27 vs. E. coli OP50 exposure; 4hours GSE36493: C. elegans young adults: Exposed to Staphylococcus aureus versus exposed to E. coli OP50 : 4 hours GSE36499: C. elegans young adults: Exposed to Serratia marcescens versus exposed to E. coli OP50 : 4 hours GSE36501: C. elegans young adults: Exposed to Xenorhabdus nematophila versus exposed to E. coli OP50 : 4 hours GSE36517: P. pacificus young adults: Exposed to Bacillus thuringiensis DB27 versus exposed to E. coli OP50 : 4 hours GSE36519: P. pacificus young adults: Exposed to Staphylococcus aureus versus exposed to E. coli OP50 : 4 hours GSE36521: P. pacificus young adults: Exposed to Serratia marcescens versus exposed to E. coli OP50 : 4 hours GSE36523: P. pacificus young adults: Exposed to Xenorhabdus nematophila versus exposed to E. coli OP50 : 4 hours Refer to individual Series

2012-03-20 | E-GEOD-36636 | biostudies-arrayexpress

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