Dataset Information


Hepatocyte growth factor time course

ABSTRACT: Cultured Madin-Darby canine kidney (MDCK) cells treated with hepatocyte growth factor (HGF) for 0, 3 and 24 hours. Each time point in triplicate. Keywords: time-course

INSTRUMENT(S): ToxExpress GeneChip Canine Array

SUBMITTER: David Johnson  

PROVIDER: GSE578 | GEO | 2003-11-04



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Gene expression alterations during HGF-induced dedifferentiation of a renal tubular epithelial cell line (MDCK) using a novel canine DNA microarray.

Balkovetz Daniel F DF   Gerrard Edward R ER   Li Shixiong S   Johnson David D   Lee James J   Tobias John W JW   Rogers Katherine K KK   Snyder Richard W RW   Lipschutz Joshua H JH  

American journal of physiology. Renal physiology 20031209 4

Hepatocyte growth factor (HGF) elicits a broad spectrum of biological activities, including epithelial cell dedifferentiation. One of the most widely used and best-studied polarized epithelial cell lines is the Madin-Darby canine kidney (MDCK) cell line. Here, we describe and validate the early response of polarized monolayers of MDCK cells stimulated with recombinant HGF using a novel canine DNA microarray designed to query 12,473 gene sequences. In our survey, eight genes previously implicated  ...[more]

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