Genomics

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Profile of differential expression and DNA methylation status in choriodecidua of women affected with severe endometriosis [DNA methylation]


ABSTRACT: Endometriosis is a common gynecological disease that affects 10-20% of women in child-bearing age. It is defined by the presence of endometrial tissues outside the uterus. The causes remain elusive, but the endometrium of these patients differs profoundly from that of disease-free subjects. During pregnancy, the maternal-fetal interface is built onto decidualized endometrium. We investigated whether this interface is normal when the subjects suffer of endometriosis and showed remarkly properties of eutopic endometrium from endometriosis-affected women to spontaneously develop endometriotic-like lesions within direct contact to non-uterine tissues.

ORGANISM(S): Homo sapiens

PROVIDER: GSE57831 | GEO | 2014/11/10

SECONDARY ACCESSION(S): PRJNA248205

REPOSITORIES: GEO

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