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The role of AR-associated factors in androgen signaling

ABSTRACT: Prostate cancer is the most common cancer in men and AR downstream signalings promote prostate cancer cell proliferation. We identified androgen-regulated genes, CTBP2, FOXP1 and RUNX1. These factors interact with AR ligand dependently. In order to investigate androgen-regulated gene functions in prostate cancer cells, we performed gene expression in AR-positive prostate cancer cell lines after siRNA treatment. We also treated cells with vehicle or androgen to analyzed the effects of these genes on AR function.

ORGANISM(S): Homo sapiens

PROVIDER: GSE58309 | GEO | 2014/10/21

SECONDARY ACCESSION(S): PRJNA251976

REPOSITORIES: GEO

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The role of AR-associated factors in androgen signaling

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