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Gene expression from aged and young dorsal root ganglia after nerve injury

ABSTRACT: Sciatic nerve crush was performed on cohorts of 2-month and 24-month old animals. Resulting gene-expression data were generated from dorsal root ganglia 5 days after injury compared to naïve animals. Results show differences in intrinsic growth responses with normal aging.

ORGANISM(S): Mus musculus

PROVIDER: GSE58982 | GEO | 2014/07/30

SECONDARY ACCESSION(S): PRJNA254040

REPOSITORIES: GEO

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Gene expression from aged and young dorsal root ganglia after nerve injury

Project description:Sciatic nerve crush was performed on cohorts of 2-month and 24-month old animals. Resulting gene-expression data were generated from dorsal root ganglia 5 days after injury compared to naïve animals. Results show differences in intrinsic growth responses with normal aging. Total RNA taken from L4 and L5 dorsal root ganglia 5 days after injury 2-month and 24-month old animals at either day 0 or day 5 after sciatic nerve crush injury.

2014-07-30 | E-GEOD-58982 | biostudies-arrayexpress

Gene expression from aged and young sciatic nerve after nerve injury

Project description:Sciatic nerve ligation was performed on cohorts of 2-month and 24-month old animals. Resulting gene-expression data were generated from sciatic nerve 1 and 4 days after injury compared to naïve animals. Results show differences in sciatic nerve responses with normal aging. Total RNA taken from sciatic nerves from 2-month and 24-month old animals at either day 0, 1 and 4 after sciatic nerve crush injury.

2014-07-30 | E-GEOD-59040 | biostudies-arrayexpress

Gene expression from aged and young sciatic nerve after nerve injury

2014-07-30 | GSE59040 | GEO

Quantification of oxidized proteins in wild type and Nox2 deficient mouse dorsal root ganglia

Project description:Here we studied the NOX2 dependent redox-proteome in dorsal root ganglia in mice. The overall goal was to assess the degree of NOX2-dependent changes in oxidised proteins following exposure to enriched enviroment and sciatic nerve axotomy in dorsal root ganglia.

2020-10-13 | PXD018085 | Pride

RNA sequencing of whole sciatic Dorsal Root Ganglia (DRG) from young and aged mice

Project description:Purpose: compare the gene expression in whole sciatic DRG of aged mice preceding and after sciatic nerve injury (SNI) compared to the young Results: we found ageing-dependent gene expression changes repressing axonal regeneration following sciatic nerve injury

2022-01-01 | GSE149770 | GEO

Whole-genome gene expression profiling of dorsal root ganglion neurons after nerve damage

Project description:We generated whole-genome gene expression profiles of dorsal root ganglion (DRG) neurons following nerve damage. DRG neurons extend one peripheral axon into the spinal nerve and one central axon into the dorsal root. The peripheral axon regenerates vigorously, while in contrast the central axon has little regenerative capacity. For this study, two groups of animals were subjected either to sciatic nerve (SN) or dorsal root (DR) crush, and at 12, 24, 72 hours and 7 days after the crush, lumbar DRGs L4, L5 and L6 were dissected and total RNA was extracted. For each time point after lesion, three biological replicate RNA samples were hybridized together with the common reference sample consisting of labeld RNA pooled from three unlesioned animals.

2010-09-01 | E-GEOD-21007 | biostudies-arrayexpress

A Transcriptomic Analysis of Neuropathic Pain in Rat Dorsal Root Ganglia Following Peripheral Nerve Injury

Project description:In this study, we screened the differentially expressed genes (DEGs) in the dorsal root ganglia (DRG) from rats with sham or partial sciatic nerve ligation (pSNL) surgery 7 days using RNAseq technique to explore the molecular mechanisms of neuropathic pain

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Whole-genome gene expression profiling of dorsal root ganglion neurons after nerve damage

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RNA sequencing of whole sciatic Dorsal Root Ganglia (DRG) from young and aged mice

Project description:RNA sequencing of whole sciatic Dorsal Root Ganglia (DRG) from young and aged mice

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Dorsal root ganglia (DRG) and Sciatic nerve (SCN) in female BTBR ob/ob mice - diabetic peripheral neuropathy

Project description:Female mouse models of diabetic peripheral neuropathy (DPN) have not yet been identified. Our aim is firstly to demonstrate that female BTBR ob/ob mice display robust DPN and secondly, to perform relevant comparisons with non-diabetic and gender-matched controls. Lastly, microarray technology was employed to identify dysregulated genes and pathways in the SCN and DRG of female BTBR mice. Dorsal root ganglia (DRG) and sciatic nerve (SCN) were removed from female mice, RNA isolated and processed for gene expression profiling to identify differentially expressed genes using Affymetrix GeneChip Mouse Genome 430 2.0 Arrays.

2016-07-12 | GSE70852 | GEO

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