Transcriptomics

Dataset Information

0

Zinc acquisition in Pseudomonas aeruginosa


ABSTRACT: This study addresses the impact of zinc limitation on the opportunistic human pathogen, Pseudomonas aeruginosa. Zinc limitation was assessed in the P. aeruginosa PAO1 strain using an isogenic deletion mutant lacking the periplasmic, zinc solute-binding protein, znuA (PA5498). ZnuA delivers bound zinc to its cognate ABC transporter, ZnuBC, for import into the cytoplasm. Our transcriptional analyses revealed P. aeruginosa to possess a multitude of zinc acquisition mechanisms, each of which were highly up-regulated in the zinc-deficient znuA mutant strain. P. aeruginosa also utilized zinc-independent paralogues of zinc-dependent genes to maintain cellular function under zinc limitation. Together, these data reveal the complex transcriptional response and versatility of P. aeruginosa to zinc depletion.

ORGANISM(S): Pseudomonas aeruginosa PAO1

PROVIDER: GSE60177 | GEO | 2017/01/01

SECONDARY ACCESSION(S): PRJNA257669

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2008-02-22 | GSE9255 | GEO
2013-06-21 | GSE47173 | GEO
2008-06-16 | E-GEOD-8408 | biostudies-arrayexpress
2016-01-26 | GSE77163 | GEO
2013-06-21 | E-GEOD-47173 | biostudies-arrayexpress
2014-01-01 | GSE51409 | GEO
2009-06-22 | GSE8408 | GEO
2020-10-28 | GSE160188 | GEO
2020-10-28 | GSE160187 | GEO
2019-03-13 | GSE122253 | GEO