Transcriptomics

Dataset Information

32

YAP and RUNX co-regulated genes in MCF10A


ABSTRACT: An antagonistic interplay between YAP and RUNX where RUNX proteins abrogate YAP-mediated transcription of EMT and Stemness associated genes in mammary epithelial cells in an interaction dependent manner. Overall design: YAP and RUNX1 or RUNX3 were stably expressed together or alone in MCF10A cell line. Genes that are co-regulated by both were studied in the context of breast cancer.

INSTRUMENT(S): [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]

ORGANISM(S): Homo sapiens  

SUBMITTER: Tuan Zea Tan  

PROVIDER: GSE60876 | GEO | 2018-02-26

REPOSITORIES: GEO

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Publications

RUNX1 and RUNX3 protect against YAP-mediated EMT, stem-ness and shorter survival outcomes in breast cancer.

Kulkarni Madhura M   Tan Tuan Zea TZ   Syed Sulaiman Nurfarhanah Bte NB   Lamar John M JM   Bansal Prashali P   Cui Jianzhou J   Qiao Yiting Y   Ito Yoshiaki Y  

Oncotarget 20180206 18


Hippo pathway target, YAP has emerged as an important player in solid tumor progression. Here, we identify RUNX1 and RUNX3 as novel negative regulators of oncogenic function of YAP in the context of breast cancer. RUNX proteins are one of the first transcription factors identified to interact with YAP. RUNX1 or RUNX3 expression abrogates YAP-mediated pro-tumorigenic properties of mammary epithelial cell lines in an interaction dependent manner. RUNX1 and RUNX3 inhibit YAP-mediated migration and  ...[more]

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