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Genome-wide analysis expression of ileum samples from PGC-1β fl/? and iKOPGC-1β

ABSTRACT: Analysis of metabolic pathway gene expression. The hypothesis tested in the present study is to assess mRNA level changes in metabolic genes in enterocytes from intestine specific PGC-1β konckout mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE61640 | GEO | 2015/03/01

SECONDARY ACCESSION(S): PRJNA261732

REPOSITORIES: GEO

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Genome-wide analysis expression of ileum samples from PGC-1β fl/? and iKOPGC-1β

Project description:Analysis of metabolic pathway gene expression. The hypothesis tested in the present study is to assess mRNA level changes in metabolic genes in enterocytes from intestine specific PGC-1β konckout mice. Total RNA obtained from ileum samples from IKOPGC-1β mice was compared to the total RNA extracted from their wild-type littermates.

2015-03-01 | E-GEOD-61640 | biostudies-arrayexpress

Genome-wide analysis expression of ileum samples from wild-type and iPGC-1β

Project description:Analysis of metabolic pathway gene expression. The hypothesis tested in the present study is to assess mRNA level changes in metabolic genes in enterocytes from transgenic mice overexpressing PGC-1β specifically in the intestine. Total RNA obtained from ileum samples from iPGC-1β mice was compared to the total RNA extracted from their wild-type littermates.

2015-03-01 | E-GEOD-61641 | biostudies-arrayexpress

Genome-wide analysis expression of ileum samples from wild-type and iPGC-1β

2015-03-01 | GSE61641 | GEO

Genome-wide analysis expression of ileum tumor samples from FVBN/APCmin and iPGC-1β/APCmin

Project description:Analysis of metabolic pathway gene expression. The hypothesis tested in the present study is to assess mRNA level changes in metabolic genes in intestinal tumors from APCmin mice overexpressing PGC-1β specifically in the intestine. Total RNA obtained from ileum tumor samples from iPGC-1β/APCmin mice was compared to the total RNA extracted from FVBN/APCmin mice.

2015-03-01 | E-GEOD-61642 | biostudies-arrayexpress

Genome-wide analysis expression of ileum tumor samples from FVBN/APCmin and iPGC-1β/APCmin

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Hepatic microRNA Expression by PGC-1α and PGC-1β in the Mouse II

Project description:Hepatic microRNA Expression by PGC-1α and PGC-1β in the Mouse II

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Hepatic microRNA Expression by PGC-1α and PGC-1β in the Mouse I

Project description:Hepatic microRNA Expression by PGC-1α and PGC-1β in the Mouse I

| PRJNA595600 | ENA

The transcriptional coregulator PGC-1β controls mitochondrial function and anti-oxidant defense in skeletal muscles

Project description:Transcriptional microarray analysis was conducted on gastrocnemius muscle of control and PGC-1β(i)skm-/- mice one week after the last tamoxifen administration using the Affymetrix Mouse Gene 1.0 ST.

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Complementary action of the PGC-1 coactivators in mitochondrial biogenesis and brown fat differentiation

Project description:Mitochondria play an essential role in the ability of brown fat to generate heat, and the PGC-1 coactivators control several aspects of mitochondrial biogenesis. To investigate their specific roles in brown fat cells, we generated immortal preadipocyte lines from the brown adipose tissue of mice lacking PGC-1α. We could then efficiently knockdown PGC-1β expression by shRNA expression. Loss of PGC-1α did not alter brown fat differentiation but severely reduced the induction of thermogenic genes. Cells deficient in either PGC-1α or PGC-1β coactivators showed a small decrease in the differentiation-dependant program of mitochondrial biogenesis and respiration; however, this increase in mitochondrial number and function was totally abolished during brown fat differentiation when both PGC-1α and PGC-1β were deficient. These data show that PGC-1α is essential for brown fat thermogenesis but not brown fat differentiation, and the PGC-1 coactivators play an absolutely essential but complementary function in differentiation-induced mitochondrial biogenesis. Affymetrix microarray analysis of total RNA from wt, PGC-1α KO and PGC-1α KO cells expressing an RNAi specific for PGC-1β knockdown was performed. Of the 461 mitochondrial genes analyzed, 181 were found to be at least 20% different between wt and defective PGC-1α and β adipocytes (p < 0.05). More than 85% of these genes were downregulated in cells deficient for PGC-1alpha and PGC-1beta. Keywords: Analysis of mitochondrial gene expression

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Hepatic microRNA Expression by PGC-1α and PGC-1β in the Mouse I

Project description:The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor-γ coactivators (PGC-1s) are transcriptional key players of liver metabolism, able to regulate mitochondrial function, gluconeogenesis and lipid metabolism. Their activity is accurately modulated by post-translational modifications. Here, we showed that specific PGC-1s expression can lead to the upregulation of different microRNAs widely implicated in liver physiology and diseases development and progression, thus offering a new layer of complexity in the control of hepatic metabolism.

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