Dataset Information


Nasal Mucosal miRNA expression in RSV positive infants with mild or severe disease, compared to healthy controls

ABSTRACT: The aim of this investigation was two-fold: i) to describe miRNAs involved in the immune response to Respiratory syncytial virus (RSV) in a clinical setting in order to inform further research of immune system regulation by miRNAs in RSV or other infections; ii) to discover differences in miRNA expression between disease severity groups. We have therefore profiled miRNA in cytology brushings of the nasal mucosa in infants with RSV disease, comparing them to healthy infants. miRNA microarray identified 26 differentially regulated miRNA which were subsequently analyzed by RT-qPCR. Overall design: Nasal mucosal samples were taken from RSV positive infants using cytology brushes on admission to hospital after aspiration of nasal secretions. Samples were taken from healthy controls without clinical symptoms of respiratory infection using the same procedure.

INSTRUMENT(S): Agilent-029297 Human miRNA Microarray (probe name version)

SUBMITTER: Christopher Stephen Inchley  

PROVIDER: GSE62306 | GEO | 2014-10-15



Dataset's files

Action DRS
GSE62306_RAW.tar Raw
filelist.txt Txt
Items per page:
1 - 2 of 2

Similar Datasets

2015-01-01 | S-EPMC4387708 | BioStudies
2016-01-01 | S-EPMC6215710 | BioStudies
2018-01-01 | S-EPMC6174252 | BioStudies
2017-01-01 | S-EPMC5625849 | BioStudies
1000-01-01 | S-EPMC4505261 | BioStudies
2017-01-01 | S-EPMC5627276 | BioStudies
1000-01-01 | S-EPMC5279754 | BioStudies
2020-01-01 | S-EPMC7316634 | BioStudies
2014-01-01 | S-EPMC3940902 | BioStudies
2017-01-01 | S-EPMC5541395 | BioStudies