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Comparasion between SKOV3-shRNARELB and SKOV3-shRNALuc

ABSTRACT: Analysis of genes differentially expressed in ovarian cancer cells with sirna of Rel B in transient transfections was performed.

ORGANISM(S): Homo sapiens

PROVIDER: GSE62815 | GEO | 2015/10/31

SECONDARY ACCESSION(S): PRJNA265203

REPOSITORIES: GEO

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Comparasion between SKOV3-shRNARELB and SKOV3-shRNALuc

Project description:Analysis of genes differentially expressed in ovarian cancer cells with sirna of Rel B in transient transfections was performed. Two groups were analyzed in triplicate each. The First group was SKOVÂ· cells transfected with iRNARelB and the other group was transfected with siRNALuciferase.

2015-10-31 | E-GEOD-62815 | biostudies-arrayexpress

Comparasion between MCF7-NIK overexpressing cells, MCF7-control cells and MCF7-NIK depleted cells

Project description:Analysis of differentially expressed genes in MCF7 cancer cells transfected with an expression vector containing the ORF of NIK, a shRNA of NIK and a control shRNA. Transient transfections were performed in triplicates . We use micorarrays to elucidate the machanisms by which NIK regulates stem cells biology

2015-11-30 | GSE63382 | GEO

Expression data from SKOV3 KO1#_Vector and SKOV3 KO1#_MED12 rescued cells

Project description:Epithelial ovarian cancer (EOC) is the leading cause of death among all gynecological malignancies due to high rate of disease relapse. Disease relapse in cancer patients after clinical remission are often referred to tumor dormancy. Here we identify the RNA polymerase II transcriptional Mediator subunit 12 (MED12) as an important molecular regulator of tumor dormancy. We found that MED12 knock-out (KO) could induce dormancy of EOC cells in vitro and in vivo. Mechanistically, microarray analysis showed that MED12 KO decreased the expression of EGFR. Hierarchical cluster assays of the differentially expressed genes between SKOV3 KO1#_Vector and SKOV3 KO1#_MED12 cells

2018-04-10 | GSE112887 | GEO

Microarray to identify the differentially expressed genes in CFG treated SKOV3 cells compared with control cells under TGFbeta condition

Project description:The compound fuling granule (CFG) is a traditional Chinese drug which has been used to treat ovarian cancer in China for over twenty years. Nevertheless, the underlying molecular mechanism of its anti-cancer effect remains unclear. In this study, microarray data analysis was performed to search for differentially expressed genes in CFG-treated ovarian cancer cells. Several cell cycle and epithelial-mesenchymal transition (EMT) related genes were identified. The microarray analyses also revealed that CFG potentially regulates EMT in ovarian cancer. 9 samples are analyzed, and 3 samples for each group,

2016-03-22 | E-GEOD-79454 | biostudies-arrayexpress

Microarray to identify the differentially expressed genes in CFG treated SKOV3 cells compared with control cells under TGFbeta condition

2016-03-22 | GSE79454 | GEO

Homo sapiens

Project description:Role of CSN5 in breast cancer (siRNA transfections)

| PRJNA105247 | ENA

Differential gene expression profiles between SKOV3.ip1-S116A cells (Ser116 of PEA-15 substituted with alanine) and SKOV3.ip1-S116D cells (Ser116 of PEA-15 substituted with aspartic acid).

Project description:To dissect the molecular mechanisms of PEA-15-mediated paclitaxel sensitization in ovarian cancer cells, we performed cDNA microarray analysis using SKOV3.ip1-S116A cells (Ser116 of PEA-15 substituted with alanine) and SKOV3.ip1-S116D cells (Ser116 of PEA-15 substituted with aspartic acid). cDNA microarray data analysis showed that SCLIP (SCG10-like protein), also known as STMN3, was highly expressed in SKOV3.ip1-S116D cells and was involved in pPEA-15-mediated paclitaxel sensitization in ovarian cancer cells.

2012-05-12 | GSE37934 | GEO

Analysis of gene expression in SKOV3 ovarian cancer cells after knockdown of the long non-coding RNA DNM3OS

Project description:RNA-sequencing was performed to gain insight into the mechanism responsible for the mesenchymal-to-epithelial transition (MET) induced by loss of long non-coding RNA (lncRNA) DNM3OS in SKOV3 ovarian cancer cells. Following siRNA-mediated knockdown of DNM3OS or non-targeting control, RNA-sequencing was performed. This high-throughput data revealed knockdown of DNM3OS down-regulated the expression of genes and pathways known to induce EMT in ovarian cancer.

2018-02-13 | GSE104295 | GEO

RNAseq of SKOV3(AA) and SKOV3(CC)

Project description:To study the effect of rs1192691 on ovarian cancer cells, we generated SKOV3(CC) from SKOV3(A/A) using CRISPR/Cas9 technology and performed RNA-seq.

2022-01-18 | GSE181884 | GEO

Sequencing in transcriptomes in Ovarian cancer cell line SKOV3 and bevacizumab-treated SKOV3

Project description:To investigate the possible mechanism of bevacizumab resistance in ovarian cancer ,we examined the changes in gene expression of SKOV3 before and after bevacizumab intervention. Results provide insight into molecular mechanisms of acquired resistance to bevacizumab in ovarian cancer.

2023-12-31 | GSE165419 | GEO

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