Ontology highlight
ABSTRACT:
INSTRUMENT(S): Illumina MouseWG-6 v2.0 expression beadchip
SUBMITTER: Minna Woo
PROVIDER: GSE63051 | GEO | 2014-11-07
SECONDARY ACCESSION(S): PRJNA266518
REPOSITORIES: GEO
Nature communications 20150616
Reactive oxygen species (ROS) have been linked to a wide variety of pathologies, including obesity and diabetes, but ROS also act as endogenous signalling molecules, regulating numerous biological processes. DJ-1 is one of the most evolutionarily conserved proteins across species, and mutations in DJ-1 have been linked to some cases of Parkinson's disease. Here we show that DJ-1 maintains cellular metabolic homeostasis via modulating ROS levels in murine skeletal muscles, revealing a role of DJ- ...[more]