Dataset Information


Genome-wide ChIP-seq binding profiles and linked gene expression arrays [ChIP-seq]

ABSTRACT: Pu.1-mutated murine AML cell line X18.1.1 transfected with inducible Pu.1 (PuER) or empty vector (EV) and clonal lines selected. Cells were induced with OHT for 2 hours prior to collection for ChIP-Seq and expression arrays. Overall design: Examination of transcription factors Pu.1 and CEBPA and histone mark H3K27Ac by ChIP-Seq.

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Evangelia Diamanti  

PROVIDER: GSE63317 | GEO | 2015-07-20



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Genome-scale definition of the transcriptional programme associated with compromised PU.1 activity in acute myeloid leukaemia.

Sive J I JI   Basilico S S   Hannah R R   Kinston S J SJ   Calero-Nieto F J FJ   Göttgens B B  

Leukemia 20150701 1

Transcriptional dysregulation is associated with haematological malignancy. Although mutations of the key haematopoietic transcription factor PU.1 are rare in human acute myeloid leukaemia (AML), they are common in murine models of radiation-induced AML, and PU.1 downregulation and/or dysfunction has been described in human AML patients carrying the fusion oncogenes RUNX1-ETO and PML-RARA. To study the transcriptional programmes associated with compromised PU.1 activity, we adapted a Pu.1-mutate  ...[more]

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