Transcriptomics,Genomics

Dataset Information

31

Density variation of MCF10A human breast epithelial cells


ABSTRACT: Response of mammary epithelial cells to different cell densities Overall design: Cells were plated in 35 mm dishes at 50K, 100K, 200K, 400K, 600K, and 800K, cultured for 24h, then isolated for RNA.

INSTRUMENT(S): [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

SUBMITTER: Derek Charles Radisky  

PROVIDER: GSE63353 | GEO | 2015-11-17

SECONDARY ACCESSION(S): PRJNA267559

REPOSITORIES: GEO

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Publications

Regulation of epithelial-mesenchymal transition in breast cancer cells by cell contact and adhesion.

Cichon Magdalena A MA   Nelson Celeste M CM   Radisky Derek C DC  

Cancer informatics 20150209 Suppl 3


Epithelial-mesenchymal transition (EMT) is a physiological program that is activated during cancer cell invasion and metastasis. We show here that EMT-related processes are linked to a broad and conserved program of transcriptional alterations that are influenced by cell contact and adhesion. Using cultured human breast cancer and mouse mammary epithelial cells, we find that reduced cell density, conditions under which cell contact is reduced, leads to reduced expression of genes associated with  ...[more]

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