Dataset Information


U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3’ End Formation

ABSTRACT: We sequenced mRNA from Ba/F3 cells with U2AF35(S34F) expressing or parental Ba/F3 Overall design: Examination of alternative splicing between U2AF35(S34F) expressing and parental Ba/F3

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Sung Mi Park  

PROVIDER: GSE63404 | GEO | 2016-05-01



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U2AF35(S34F) Promotes Transformation by Directing Aberrant ATG7 Pre-mRNA 3' End Formation.

Park Sung Mi SM   Ou Jianhong J   Chamberlain Lynn L   Simone Tessa M TM   Yang Huan H   Virbasius Ching-Man CM   Ali Abdullah M AM   Zhu Lihua Julie LJ   Mukherjee Siddhartha S   Raza Azra A   Green Michael R MR  

Molecular cell 20160512 4

Recurrent mutations in the splicing factor U2AF35 are found in several cancers and myelodysplastic syndrome (MDS). How oncogenic U2AF35 mutants promote transformation remains to be determined. Here we derive cell lines transformed by the oncogenic U2AF35(S34F) mutant and identify aberrantly processed pre-mRNAs by deep sequencing. We find that in U2AF35(S34F)-transformed cells the autophagy-related factor 7 (Atg7) pre-mRNA is abnormally processed, which unexpectedly is not due to altered splicing  ...[more]

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