Mechanisms of pparγ activation by non-steroidal anti-inflammatory drugs and GQ16.

ABSTRACT: This study was undertaken to assess the similarities (or differences) between the well-established PPARγ agonist Rosiglitazone and Non-steroidal anti-inflammatory drugs (NSAIDs) diclofenac, indomethacin and ibuprofen, as well as the partial agonist GQ16 at the transcriptome level. Assessment of NSAID and GQ16 activities in PPARγ-dependent 3T3-L1 cells reveals that NSAIDs and GQ16 display similar effects toward PPARγ-dependent target genes in a manner similar to that of Rosiglitazone.

ORGANISM(S): Mus musculus

PROVIDER: GSE64075 | GEO | 2015/06/01

SECONDARY ACCESSION(S): PRJNA270064

REPOSITORIES: GEO