Dataset Information


Jmjd2a and Jmjd2c regulate H3K9me3 and H3K36me3 at H3K4me3 positive transcription start sites being essential for ESC self-renewal and embryogenesis

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina HiSeq 2000 (Mus musculus)

SUBMITTER: Marianne Terndrup Pedersen  

PROVIDER: GSE64254 | GEO | 2016-05-09



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Continual removal of H3K9 promoter methylation by Jmjd2 demethylases is vital for ESC self-renewal and early development.

Pedersen Marianne Terndrup MT   Kooistra Susanne Marije SM   Radzisheuskaya Aliaksandra A   Laugesen Anne A   Johansen Jens Vilstrup JV   Hayward Daniel Geoffrey DG   Nilsson Jakob J   Agger Karl K   Helin Kristian K  

The EMBO journal 20160606 14

Chromatin-associated proteins are essential for the specification and maintenance of cell identity. They exert these functions through modulating and maintaining transcriptional patterns. To elucidate the functions of the Jmjd2 family of H3K9/H3K36 histone demethylases, we generated conditional Jmjd2a/Kdm4a, Jmjd2b/Kdm4b and Jmjd2c/Kdm4c/Gasc1 single, double and triple knockout mouse embryonic stem cells (ESCs). We report that while individual Jmjd2 family members are dispensable for ESC mainten  ...[more]

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