Genomics

Dataset Information

156

Tissue overgrowth induced by coexpression of the progenitor genes hth/MEIS1 and tsh/TSHZ results from an imbalance in the estrogen response pathway in Drosophila [FAIRE-Seq]


ABSTRACT: Analysis of third instar eye-antennal Drosophila imaginal discs with forced expression of hth, tsh or hth+tsh in the eye using an eye-specific GAL4 driver (optix2.3-GAL4). Forced maintenance of hth+tsh expression (but not of any of the two alone) results in overgrowth and aberrant cell differentiation. Results provide insight into new targets of hth+tsh. Overall design: RNA-seq gene expression profiling across Drosophila 3rd instar larval wild type eye-antennal discs and genetic perturbations of tsh, hth and tsh-hth together.

INSTRUMENT(S): Illumina HiSeq 2000 (Drosophila melanogaster)

SUBMITTER: Stein Aerts  

PROVIDER: GSE65250 | GEO | 2017-08-31

SECONDARY ACCESSION(S): PRJNA273499

REPOSITORIES: GEO

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Publications

Nuclear receptors connect progenitor transcription factors to cell cycle control.

Neto Marta M   Naval-Sánchez Marina M   Potier Delphine D   Pereira Paulo S PS   Geerts Dirk D   Aerts Stein S   Casares Fernando F  

Scientific reports 20170707 1


The specification and growth of organs is controlled simultaneously by networks of transcription factors. While the connection between these transcription factors with fate determinants is increasingly clear, how they establish the link with the cell cycle is far less understood. Here we investigate this link in the developing Drosophila eye, where two transcription factors, the MEIS1 homologue hth and the Zn-finger tsh, synergize to stimulate the proliferation of naïve eye progenitors. Experime  ...[more]

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