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Gene expression profiles during human lung tumorigenesis

ABSTRACT: Some tumor initiation processes as well as genetic and genomic changes during human lung tumorigenesis have been progressively revealed. In our study, we elucidated expression profiles in normal human airway epithelium cells from non-smokers, immortalized human bronchial epithelial cell lines and lung squamous cell carcinoma tissues. Collectively, these cells reflect a progressively increasing degree of malignancy. Furthermore, from its earliest stages, lung tumorigenesis may be associated with decreased IFN alpha/beta signaling, and this association may provide insights for the selection of high-risk lung cancer patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE67061 | GEO | 2016/03/19

SECONDARY ACCESSION(S): PRJNA278839

REPOSITORIES: GEO

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