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Epigenome Analysis of Post-Mortem Human Temporal Pole Brain Tissue

ABSTRACT: Epigenome Analysis of Post-Mortem Human Temporal Pole Brain Tissue For more information, please refer to DOI: 10.3233/JAD-141989

ORGANISM(S): Homo sapiens

PROVIDER: GSE67419 | GEO | 2015/03/31

SECONDARY ACCESSION(S): PRJNA279861

REPOSITORIES: GEO

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Epigenome Analysis of Post-Mortem Human Temporal Pole Brain Tissue

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2015-03-31 | E-GEOD-67419 | biostudies-arrayexpress

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Comparison of post-mortem tissue from Brodman Brain BA22 region between schizophrenic and control patients

Project description:Transcriptional analysis of the superior temporal cortex (BA22) in schizophrenia: Pathway insight into disease pathology and drug development Schizophrenia is a highly debilitating psychiatric disorder which is known to have heritable genetic and environmental components. To gain some insight into the mechanisms underpinning both positive and negative symptoms of the disease, we determined the genome wide expression of mRNA transcripts in post-mortem tissue from the superior temporal cortex (Brodmann Area 22, BA22) in schizophrenic and control patients. The BA22 region is known to mediate the positive pathophysiology of schizophrenia; we compared this to the anterior prefrontal cortex (BA10) from the same subjects, which is known to mediate negative symptoms. Following adjustments for confounding clinical, sample and experimental sources of variation, we carried out gene set enrichment analysis in each region using pathway data. We identified an over-representation of genes involved in cytoskeletal remodelling, neurodevelopment, cell adhesion, cellular signalling, neurotransmission and autophagy. Collectively our analysis indicates a disruption of processes underpinning synaptic plasticity in both regions. Region-specific changes support the dysregulation of distinct pathways in the BA10 and BA22 regions. This may highlight new therapeutic opportunities to treat both negative and positive symptoms of the disease. Post-mortem derived BA22 tissue from schizophrenic and control patients were compared. Age, gender, post-mortem delay and pH of brain lysates data were also captured.

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RNA-sequencing of human post-mortem brain tissues

Project description:RNA-seq profiling was conducted on clinically-annotated human post-mortem brain tissues

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Transcriptome profile of post-mortem ear and lung fibroblasts

Project description:Mouse ear and lung fibroblasts isolated from fresh tissue (0 hour) or 12 hour post-mortem tissue

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Expression data from post mortem porcine skeletal muscle

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