Transcriptomics,Genomics

Dataset Information

37

Muscle-specific gene expression changes in normal and high-fat diet in spinal and bulbar muscular atrophy (SBMA)


ABSTRACT: The pattern of gene expression changes were analyzed in the skeletal muscle of knock-in mouse models of SBMA fed either a normal chow diet (NCD) or a high-fat diet (HFD). Overall design: Microarray analysis was performed in 180-day-old mice (wild type-NCD, wild type-HFD, AR113Q-NCD, and AR113Q-HFD).

INSTRUMENT(S): Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)

SUBMITTER: maria pennuto  

PROVIDER: GSE68441 | GEO | 2016-04-11

SECONDARY ACCESSION(S): PRJNA282741

REPOSITORIES: GEO

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Publications


Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by the expansion of a polyglutamine tract in the androgen receptor (AR). The mechanism by which expansion of polyglutamine in AR causes muscle atrophy is unknown. Here, we investigated pathological pathways underlying muscle atrophy in SBMA knock-in mice and patients. We show that glycolytic muscles were more severely affected than oxidative muscles in SBMA knock-in mice. Muscle atrophy was associated with early-onset, p  ...[more]

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