Dataset Information


MicroRNA data in the mouse liver at 48 hrs versus 0 hr post 70% partial hepatectomy

ABSTRACT: MicroRNAs have been reported to control liver regeneration though the underlying mechanisms remain largely unclear. We used microarrays to examine microRNA profiles in the mouse liver at 48 hrs versus 0 hr post 70% partial hepatectomy. Overall design: Mice livers at 48 hrs post partial hepatectomy (group PH-48h, n=4) and mice livers at 0 hr post partial hepatectomy (group PH-0h, n=4) were used for RNA extraction and hybridization on Affymetrix miRNA 3.0.

INSTRUMENT(S): [miRNA-3] Affymetrix Multispecies miRNA-3 Array

SUBMITTER: Yihua Bei  

PROVIDER: GSE68451 | GEO | 2017-02-10



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miR-382 targeting PTEN-Akt axis promotes liver regeneration.

Bei Yihua Y   Song Yang Y   Wang Fei F   Dimitrova-Shumkovska Jasmina J   Xiang Yang Y   Zhao Yingying Y   Liu Jingqi J   Xiao Junjie J   Yang Changqing C  

Oncotarget 20160101 2

Liver regeneration is a highly orchestrated process which can be regulated by microRNAs (miRNAs, miRs), though the mechanisms are largely unclear. This study was aimed to identify miRNAs responsible for hepatocyte proliferation during liver regeneration. Here we detected a marked elevation of miR-382 in the mouse liver at 48 hrs after partial hepatectomy (PH-48h) using microarray analysis and qRT-PCRs. miR-382 overexpression accelerated the proliferation and the G1 to S phase transition of the c  ...[more]

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