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MiR-192-EGR1/HOXB9 regulatory network controls the angiogenic switch in cancer.

ABSTRACT: A deeper mechanistic understanding of tumor angiogenesis regulation is needed to improve current anti-angiogenic therapies, which thus far have only modestly improved patient survival. We present converging evidence from systems-based miRNA analyses of large-scale patient datasets along with in vitro and in vivo experiments that identify miR-192 as a key regulator of angiogenesis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE69990 | GEO | 2016/03/21

SECONDARY ACCESSION(S): PRJNA287354

REPOSITORIES: GEO

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A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer.

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